Wells Fargo Center sits on the site of the old Northwestern National Bank Building, which was damaged in a fire in 1982 and imploded two years later.

Despite Norwest's adoption of the Wells Fargo identity after acquiring the latter and moving to San Francisco in 1998, significant regional operations are still maintained in this building.

It is lit from sunset through midnight by floodlights pointing up from the setback rooftops, illuminating the sides of the building's upper floors.

[4] In 1989, the building was praised by the Urban Land Institute, who honored it with their Award for Excellence in Large Scale Office Development.

[6] As of April 2019, Starwood Capital Group acquired Wells Fargo Center for $315 million.