Ncube was instrumental in the negotiations of the Global Political Agreement (GPA) that led to the formation of the Zimbabwean Government of National Unity (GNU) in 2009.
In this administration, he was appointed as the Minister of Industry and Commerce, where he worked to address the challenges facing Zimbabwe's economy, including efforts to improve trade and investment.
Ncube also chaired the COMESA (Common Market for Eastern and Southern Africa) Council of Ministers, where he was involved in regional economic cooperation initiatives.
[2] Ncube grew up under the mentorship of local Seventh-day Adventist Pastor Loyiso Ndlovu, and he followed the teachings of "Prophetess" Ellen G White.
Amendment No 19 in 2008 paved the way for the implementation of the power-sharing agreement which formed the Government of National Unity, made of ZANU PF, MDC-T and the MDC.
This Bill would amend the Constitution in the following principal respects: firstly, to substitute the Chapter on Citizenship by another Chapter making more comprehensive provision on the same topic; secondly, to make specific provision for the appointment and functions of the committee of Parliament known as the Committee on Standing Rules and Orders; thirdly, to provide that the appointment by the President of the chairperson of Zimbabwe Electoral Commission, and of the members of the Anti-Corruption Commission, must be done in consultation with the Committee on Standing Rules and Orders; fourthly to provide for the appointment and functions of a Zimbabwe Media Commission; and finally to make certain transitional amendments pursuant to the agreement between the Presidents of the Zimbabwe African National Union-Patriotic Front (ZANU-PF) and the two formations of the Movement for Democratic Change (MDC), on resolving the challenges facing Zimbabwe, which was signed in Harare on 15 September 2008.
Ncube, together with Priscila Misihairabwi –Mushonga (representing MDC) Nicholas Goche and Patrick Chinamasa (ZANU PF), and Tendai Biti and Elton Mangoma (MDC-T) constituted the team of negotiators which negotiated the Global Political Agreement (GPA) under the auspices of the then South African President Thabo Mbeki who was the SADC appointed facilitator to the Zimbabwe political dialogue during 2008.
[6] In his capacity as the Minister of Commerce and Industry, Ncube sourced funds amounting to US$40 million from the international community to revitalize distressed companies in marginalized areas.
In fear that Ncube would be looked to provide solutions to solve Zimbabwe's high unemployment rate, ZANU PF ministers refused to grant the need clearance.
When Ncube took over the leadership of the MDC in February 2011, his party nominated him to replace Professor Arthur Mutambara as the Deputy Minister in the Inclusive Government.
Ncube ran as his party's presidential candidate in the highly disputed July 2013 harmonized elections and came third after Robert Mugabe and Morgan Tsvangirai.
His cabinet in the GNU proved popular with the likes of individuals such as David Coltart, who brought much-needed innovation to the Sports and Education Ministry.
Using a peaceful non-violent approach to issues, many respect Ncube as a leader with great potential to effect lasting change and lead in a professional, open manner.
[9] Morgan Tsvangirai (Prime Minister) Arthur Mutambara / Thokozani Khuphe (Deputy Prime Ministers) Tendai Biti (Finance) Elphas Mukonoweshuro ( Public Service) Henry Dzinotyiwei (Science and Technology Development) Elton Mangoma (Economic Planning and Investment Promotion) Priscilla Misihairabwi-Mushonga (Regional Integration and International Cooperation) Giles Mutsekwa / Kembo Mohadi (Home Affairs) Henry Madzorera (Health and Child Welfare) David Coltart (Education, Sport and Culture) Eric Matinenga (Constitutional and Parliamentary Affairs) Olivia Muchena (Women Affairs, Gender and Community Development Emmerson Mnangagwa (Defence) Saviour Kasukuwere (Youth Development, Indigenisation and Empowerment) Ignatius Chombo (Local Government and Urban Development) Patrick Chinamasa (Justice ) Joseph Made (Agriculture) Herbert Murerwa (Lands and Land Resettlement) Francis Nhema (Environment) Walter Mzembi (Tourism) Nicholas Goche (Transport) Obert Mpofu (Mines and Mining Development) Samuel Sipepa Nkomo (State Enterprise and Parastatals) Nelson Chamisa (Information and Communications Technology) Welshman Ncube (Industry and Commerce) Theresa Makoni (Public Works) Fidelis Mhashu (National Housing and Social Amenities) Elias Mudzuri (Energy and Power Development) Joel Gabuza (Water Resources and Development Paurine Mpariwa (Labour and Social Welfare Simbarashe Mumbengegwi (Foreign Affairs) Webster Shamu (Information and Publicity) Stan Mudenge (Higher and Tertiary Education)