It lies on the Ruhr–Sieg railway, running from Hagen to Siegen and was opened in 1861 with the commissioning of the line.

From 1887 to 1955 Werdohl was also the terminus of a narrow-gauge railway line to Lüdenscheid operated by the Altena District Railway (Kreis Altenaer Eisenbahn).

Since the end of December 2012 Werdohl station is also a stop on the Sauerland-Höhenflug hiking trail.

Since July 2011, the station has been extensively renovated by the Werdohl municipality.

In addition, the main entrance is currently being modified to provide barrier-free access.