The school is located on the city's west side, near the intersection of Interstates 20 and 95.

In 2020, Governor Henry McMaster delivered the commencement address at the school's graduation ceremony amid the COVID-19 pandemic.

[2] On March 3, 2010, Lord Mayor of Westminster Duncan Sandys presented a formal invitation to West Florence High School Director of Bands Steve Rummage, requesting that the West Florence Marching Knights participate and perform in the city of London's 2012 New Year's Day Parade.

This parade was designated as the first official event of the 2012 Olympics, hosted in London.

[3] Because of this honor, the South Carolina State Legislature introduced and adopted Senate Resolution 712, to honor and congratulate the West Florence Knights Marching Band.