[1] It is primarily an urban residential neighborhood with retail along Main Street and pockets of industrial buildings along the train tracks.

It is lined with retail, consisting of several large supermarkets, churches, pharmacies, bank branches, a few bars and restaurants as well as a few mom and pop shops.

The West Side is home to Lourdes Memorial Hospital, Recreation Park, Binghamton High School, Seton Catholic Central, and St. Patrick's Church.

The American Civic Association, on Front Street, was the site of the Binghamton shooting, where 13 people were killed by a shooter before he committed suicide.

Apart from commercial Main Street and some industrial buildings one block north of it along the Norfolk Southern tracks, the West Side of Binghamton is primarily an urban residential neighborhood.