Mostly a two-lane, winding highway with no shoulders, Route 10 is considered to be one of substandard design when compared to modern standards.

Nevertheless, it serves as a major arterial highway in the state, carrying a substantial amount of traffic volume.

An upgrade from Man to Logan to a four-lane highway built to the same standards as the Appalachian Corridor System was completed the first part of September 2017.

Then it follows a south-eastern path parallel to several small streams and terminates into US 19 just north of Princeton, West Virginia.

In Huntington, portions of the highway are named Troy Brown Way and Hal Greer Boulevard in honor of two notable local professional athletes.