West Virginia Route 161 is a north–south state highway located entirely within McDowell County, West Virginia.

The southern terminus of the route is at West Virginia Route 16 in Bishop less than 900 feet (270 m) from the Virginia state line.

At Bishop, WV 161 enters Virginia for approximately 500 feet (150 m).

The state line follows Jacobs Fork and Horsepen Creek, which form a tight bend.

[2] There are no signs or visual indications of the state line.