The northern terminus of WV 152 is unusual in that it also serves as the southern terminus of West Virginia Route 527, which continues along the same street as it passes over Interstate 64 at exit 8 (both state routes are indicated on exit signage on the expressway).

Portions of the roadway south of Wayne run along an old Norfolk and Western Railroad bed.

Under some of the highway bridges, you can find shared abutments with the old railroad crossing.

The current designation was created in 1979, when US 52 was rerouted a few miles to the west in order to facilitate the construction of a more modern highway along the Tug Fork and Big Sandy River.

The West Virginia Department of Transportation redesignated the former segment of US 52 as WV 152 from its internal designation as route 1/52, as it formerly ran between County Route 1 and US 52.