WV 259 begins at the Virginia state line in southeastern Hardy County.

The highway continues south into Rockingham County, Virginia as SR 259 (Brocks Gap Road) toward Broadway.

The state highway passes to the east of Warden Lake and enters Hampshire County.

At Yellow Spring, the state highway veers away from the river and ascends Timber Ridge.

Carpers Pike continues northeast through Frederick County, Virginia as SR 259 toward U.S. Route 50 at Gore.