The southern terminus of the route is at West Virginia Route 3 three miles (5 km) east of Hamlin.

The northern terminus is at Interstate 77 exit 124 in Kenna.

The portion of the highway between Scott Depot and Hurricane has seen heavy commercial and residential development since the 1980s.

The area, known as Teays Valley, has grown into a major suburb of Charleston, the state's capital.

WV 34 Bus is a business loop through downtown Hurricane.