The Western Saharan spiny mouse or Aïr spiny mouse (Acomys airensis) is a species of small, insectivorous rodent in the family Muridae[2] found arid regions of western Africa.

[3] The Western Saharan spiny mouse occurs north of the Niger River and has been recorded with certainty in southern Mauritania, Mali and Niger but which may also occur in Chad, Western Sahara and southernmost parts of Algeria.

[1][3] The Western Saharan spiny mouse is terrestrial and mainly nocturnal, although some have been recorded as active during the day.

In southern Mauritania pregnant females have been found in August and October.

[1] Formerly considered conspecific with Cairo spiny mouse Acomys cahirinus but there are differences in the number of chromosomes.