The following services currently call at Wetzlar: Since the timetable change in December 2021, eight IC train pairs have been operating on the Frankfurt – Siegen – Dortmund/Unna – Münster (– Norddeich Mole) route.

In the 1980s and before, there were many daily express services from Wetzlar station to remote destinations such as Oberstdorf.

The return service from Croatia, Slovenia, and Austria reached Wetzlar in the evening and continued to Siegen.

Wetzlar station has five platform tracks, served by Regionalbahn, Regional-Express, and EuroCity trains.

Trains operate through the following platforms: East of the passenger station in the district of Garbenheim is Wetzlar freight yard, which has been the most important facility of its kind in central Hesse since December 2006.