Wheeling Creek is a tributary of the Ohio River, 25 miles (40 km) long, in the northern panhandle of West Virginia, with a watershed extending into southwestern Pennsylvania.

In the Elm Grove neighborhood of Wheeling, it collects Little Wheeling Creek,[12] which rises in Ohio County just west of the Pennsylvania state line and flows southwestwardly through the communities of Valley Grove and Triadelphia.

In Triadelphia, Little Wheeling Creek collects Middle Wheeling Creek,[13] which rises in West Finley Township in Greene County, Pennsylvania, and flows generally westwardly into southeastern Ohio County.

[15] At its mouth, the estimated mean annual flow volume of Wheeling Creek is 373.5 cubic feet per second (10.58 m3/s).

There are many entry points located alongside the Wheeling Heritage Trail System.