It is a largely residential district consisting of two-story, frame detached dwellings built in the mid- to late-19th and early-20th century, including the Irwin-Brues House (1853) and a number of houses on Zane Street.

The houses are representative of a number of popular architectural styles including Bungalow, Italianate, Queen Anne, and Colonial Revival.

Notable non-residential contributing properties include the Exposition Building (1924), Thompson United Methodist Church (1913–1915), Madison School (1916), firehouse (1930–1931), the Bridgeport Bridge (1893), the Aetnaville Bridge (1891), "The Marina," Wheeling Island Baseball Park, and "Belle Island Park."

It includes the separately listed Wheeling Suspension Bridge, Harry C. and Jessie F. Franzheim House, and John McLure House.

[1] All of the following are located in Wheeling, Ohio County, WV: