Whitewater is a village in Hubble Township in southwestern Cape Girardeau County, Missouri, United States.

Whitewater was first settled in 1866 on lands belonging to William 'Uncle Bill' DeVore and Linus Sanford.

Whitewater was situated along the St. Louis, Iron Mountain and Southern Railway.

[4][5] The first mayor of Whitewater was P. N. O'Brien who was born in St. Louis in 1851 and who had previously lived in Cape Girardeau as he had owned the J. S. Albert Grocer Company in Cape Girardeau and helped found Shell & Albert, the first mercantile business in Whitewater; O'Brien also served the Whitewater postmaster for nearly a quarter of a century.

[7] The town is on Missouri Route A, approximately seven miles west of Dutchtown.

The Headwater Diversion Channel diverts the flow of the Whitewater River just to the south of the town.

[8] According to the United States Census Bureau, the village has a total area of 0.21 square miles (0.54 km2), all land.