In 2023, the building was demolished to make room for a new K-12 combined campus on the former high school grounds.

Wickliffe High School athletic teams compete in the Chagrin Valley Conference.

On October 10, 2006, the boys varsity soccer team, coached by Chris Adkins, won its first CVC conference title defeating Chagrin Falls, 2–0.

The soccer team went on to reach the division three state championship game which they lost to Worthington Christian in a penalty kick shootout.

In 2016, the boys’ football team clinched and made in the division five OHSSA State Playoffs In 2017, the football team clinched and made the division five OHSAA State Playoffs.