[2] It is owned and operated by the Indianapolis Airport Authority and has flights to over 61 destinations in the United States, Canada, Europe, and Mexico.

Largely because of FedEx's activity, IND consistently ranks among the top 10 busiest U.S. airports in terms of air cargo throughput.

The Federal Aviation Administration (FAA) National Plan of Integrated Airport Systems for 2017–2021 categorized it as a medium hub primary commercial service facility.

[8] In 1944, it was renamed Weir Cook Municipal Airport, after US Army Air Forces Col. Harvey Weir Cook of Wilkinson, Indiana, who had become a flying ace during World War I with seven victories and had died flying a P-39 over New Caledonia in World War II.

The IAA has an eight-member board with members appointed by the mayor of Indianapolis and other officials from Marion, Hendricks, and Hamilton counties in central Indiana.

[10] The April 1957 Official Airline Guide (OAG) shows 82 weekday departures: 24 Eastern, 22 TWA, 15 Delta, 11 American, 9 Lake Central and 1 Ozark.

[12] In the late 1990s and early 2000s, Indianapolis was a hub for then locally based ATA Airlines and its regional affiliate, Chicago Express/ATA Connection.

[24] In 2021, a six-person panel of Indianapolis members of the American Institute of Architects (AIA) identified the Col. H. Weir Cook Terminal among the ten most "architecturally significant" buildings completed in the city since World War II.

[26] In August 2017, Allegiant Air announced it would open a $40 million aircraft base at the airport that would begin operations in February of the following year.

The hotel will feature a full-service restaurant, a seventh-floor lounge area with an airfield view open to the public, a fitness center, approximately 10,000 square feet (930 m2) of meeting space, and dedicated parking with valet.

Groundbreaking for the Westin Indianapolis Airport hotel is expected in spring 2025 with anticipated completion of the almost $205 million project in December 2027.

[32] Eight rental car operations and the Ground Transportation Center (where information about limousine, shuttle bus, hotel courtesy vehicles and other transportation services such as IndyGo bus service can be obtained) are located on the first floor of the attached parking garage.

All pick-ups and drop-offs of rental vehicles also occur here, eliminating the need for shuttling customers to and from individual companies' remote processing facilities.

It features a light-filled center atrium complete with a piece of suspended artwork and contains moving sidewalks to speed pedestrians into and out of the terminal building itself.