Its source region lies in the North Palatine Uplands, the northern outliers of the precipitation-rich Donnersberg massif, west of Haide in the borough of Kirchheimbolanden.

For a long time in this region, the mining of Mercury and quarrying of building stone (especially Flonheim Sandstone [de]) was important.

Today, in the source region of the stream (Winkelbach), magmatite is mined in the huge quarries on the Donnersberg and turned into ballast material.

The subsequent course of the Wiesbach through the Tertiary deposits of the Rhenish-Hessian Hills flows through a broad valley with gently sloping hillsides.

The stream flows through Oberwiesen, Nieder-Wiesen and Wendelsheim, passing there the Teufelsrutsch ("Devil’s Slide") and unites with the Finkenbach.