Zotzenheim is an Ortsgemeinde – a municipality belonging to a Verbandsgemeinde, a kind of collective municipality – in the Mainz-Bingen district in Rhineland-Palatinate, Germany.

It belongs to the Verbandsgemeinde of Sprendlingen-Gensingen, whose seat is in Sprendlingen.

On Kreuznacher Straße is found a cinder team handball court and a clubhouse.

Johann/Sprendlingen is a successful team handball club that grew out of TV Zotzenheim 1901 (gymnastic club) and has already played several times in the third handball league.

In the industrial park outside Zotzenheim on the street Am neuen Graben, several small businesses have set up shop, among them the Sand Barth shipping company.