George Norton Wilcox and Dora Isenberg planned a community hospital with a staff open to all eligible physicians on Kauaʻi.

Plantation dispensaries were phased out at this time and the eastside physicians began practice in the facilities, later forming the Kauai Medical Group Inc.

The third expansion was completed in August 1971 and resulted in the present $4.2 million Acute Patient Care Tower and Special Diagnostic and Treatment Facility.

Wilcox Medical Center treated surfer Bethany Hamilton in 2003 after she lost her arm to a 14-foot (4.3 m) tiger shark off the north shore of Kauaʻi.

Another gift of 1.8 million dollars by Dr. Priscilla Chan and Mark Zuckerberg, upgraded Wilcox's imaging center with a CT Scanner that replaced one of their two aging ones.