The Wilder-Holton House is prominently located at the northern end of Lancaster's Main Street, on the north side of the triangular junction of United States Routes 2 and 3.

It is a two-story wood-frame structure, covered by a hip roof and finished in wooden clapboards.

The main entrance faces east, sheltered by a single-story porch extending across three bays.

The interior is presently arranged as a center-hall plan, and includes a large ballroom space on the second floor.

[2] The house was built in 1780 by Jonas Wilder, and is believed to be the first two-story building to be erected in what is now Coos County.