The station was built in 1947 by the Seaboard Air Line Railroad (SAL) in the art deco architectural style, and is located on what is today CSX's S-Line, which runs along the west side of the building.

[1] In 1967, after the merger of Atlantic Coast Line Railroad (ACL) and the SAL into the new Seaboard Coast Line Railroad, the Florida Special, Silver Meteor, Silver Star, and Palmland made stops at the station from 1967 to 1971, while the Sunland was discontinued by SCL in 1968.

[2] In 1971, most passenger service in the United States was transferred to Amtrak, and the Silver Meteor retained its stop in Wildwood.

[4][5] Two years later, the Palmetto was truncated to Savannah, Georgia on November 1, 2004, prompting Amtrak to revive Silver Star service to Tampa along the CSX A-Line shared by the current Silver Meteor, and part of the suspended Sunset Limited, and finally ending passenger service to Wildwood.

Wildwood is also the western terminus of an abandoned SAL branchline that once ran to Orlando through the cities of Leesburg and Tavares.