In 1893, His discovered the bundle of His, the collection of specialized cardiac muscle cells in the heart that transmits electrical impulses and helps synchronize contraction of the cardiac muscles.

Later in life, as a professor of medicine at the University of Berlin, he was one of the first to recognize that "the heartbeat has its origin in the individual cells of heart muscle."

Werner–His disease (or trench fever) was also named after him.

Angle of His (or incisura cardiaca) was posthumously named after him by Daniel John Cunningham in 1906.

This article about a German person in the field of medicine is a stub.