From 1994 to 2002, she was co-director of excavations at the Roman port city of Berenike on the Egyptian Red Sea coast with Prof. Sidebotham from the University of Delaware.
From 2003 until 2014, Wendrich has been working as co-director of the excavations in the Fayum region of Egypt, on the North shore of Lake Qarun in cooperation with René Cappers of the Rijksuniversiteit Groningen and Simon Holdaway of the University of Auckland on the URU.
Work on the Neolithic materials resulted in the discovery of the evidence for farming in Egypt at the site Kom K. Wendrich has been involved in archaeological education as the chairperson of the board of directors at the Institute for Field Research.
Wendrich's field research has been centered on community-involvement initiatives, the most notable of which includes planning and designing several exhibitions highlighting the material culture of the indigenous Ababda nomadic communities since 1997 at the site museum in Berenike (1997), the Netherlands-Flemish Institute in Cairo (1999), the World Museum in Rotterdam, The Netherlands (2001), and the design and planning of the exhibit of Ababda Cultural Heritage Center in Wadi Gemal National Park in collaboration with Gabriel Mikhail in 2006.
In collaboration with members of the Deutsches Archäologisches Institut, Kairo, Wendrich developed the Aegeron (Ancient Egyptian Architecture Online) project.