[1] Guillaume himself entered public service as pensionary of the city of Bruges, and in this capacity was present at the abdication of Charles V. By letters patent of Philip II of Spain dated 14 May 1561, he was appointed master of requests to the Great Council of Mechelen.
On 16 December 1579, the Prince of Parma ordered loyal Catholic members of the Council of Flanders to convene at Douai under Pamele's presidency.
[1] The loyalist councillors would continue to meet in Douai until 1585, when they were able to return to Ghent.
Pamele himself was knighted by letters patent of 20 September 1581, and the same year became president of the Privy Council.
[1] His heirs were his brothers, Jean and Adolphe, who erected a monumental tomb in Brussels minster recording his achievements.