The first school began in 1887 in the attic of the old Sedwick House, with Miss Mary Wood as the first teacher,[3] and the first principal was "a Professor Baxter".

Construction of Alice High was completed in time for 1970 school year, and the first graduating class was in 1971.

Alice High School itself Met Standards under the TEA rating system, and earned distinctions in Reading/ELA and Math as of 2014.

[8] Alice High School has athletes that compete in 13 different sports, which include: Cross Country, Volleyball, Football, Basketball, Swimming, Soccer, Golf, Tennis, Track, Softball, Baseball, Power-lifting, and Cheerleading.

Since 1909 the Alice Coyotes have won 21 district titles, made 36 playoff appearances (18th all-time and 6th most in Class 4a history), and played in 4 Texas State semi-final games (1955(William Adams), 1979, 1998, and 1999).

The Alice Football team and their fans rode 20 miles in horse drawn buggies to Kingsville.

[citation needed] Current clubs at Alice High School include Art, Auto Mechanics, BPA, Band Council, Building Trades, Cheerleaders, Chorale, Cosmetology, DECA, Decathlon, Drama, Drill Team/Strutters, Environmental Club, FCCLA, FFA, Graphics, HOSA, Interact/Rotary, JETS, Junior Class, Law Enforcement, Newspaper, NHS, ROTC, Senior Class, Spanish, Student Council, TAFE, UIL, and Yearbook.

He spent the next fifty years as music supervisor and high school band director for the Alice ISD.

Following his retirement in 1993, Darleen Totten took over and has continued to promote outstanding theatre at Alice High School.

Darleen Totten also led Alice High School Drama club on an outstanding UIL OAP journey in 2011, with their production of Turandot which was also presented at the International Thespian Festival in Lincoln, Nebraska.