William Barstow Strong (May 16, 1837 – August 3, 1914) served as president of the Atchison, Topeka and Santa Fe Railway from 1881 to 1889.

[2] On July 12, 1881, he succeeded T. Jefferson Coolidge as president of the Atchison, Topeka and Santa Fe Railway (ATSF).

Strong's work with the Atchison, Topeka and Santa Fe Railway is extensively chronicled in the book From the River to the Sea by John Sedgwick.

William Barstow Strong was the name of an observation car owned by the ATSF and operated in business trains in the latter part of the 20th century.

Strong was included in a list of names that traveled aboard NASA's Stardust spacecraft which visited the comet Wild 2 in 2004.