Wynford was the son of William Best, 1st Baron Wynford, Chief Justice of the Common Pleas and his wife, Mary Anne, daughter of Jerome Knapp Jr. of Chilton in Berkshire (now Oxfordshire), Clerk of the Haberdashers' Company, by his second wife, Sarah, daughter and eventual heiress of George Noyes of Southcote, Berkshire & Andover.
He married Jane, the daughter of William Thoyts of Sulhamstead House in Berkshire and his wife, Jane, the daughter & co-heiress of Abram Newman of Mount Bures, Essex, the famous London tea merchant.
Wynford had a London home at 5 Upper Brook Street, Mayfair.
[1] Wynford sat as Member of Parliament for Mitchell (also known as St Michael's) between 1831 and 1832, when the constituency was disenfranchised through the Great Reform Act.
Lord Wynford died in February 1869, aged 71, at 7 Park Place, St James', Middlesex, and was succeeded in the barony by his eldest son, William Draper Mortimer Best, 3rd Baron Wynford.