The younger man first studied medicine at Hingham, Massachusetts, and then practiced at Warren, Rhode Island.
Bradford moved to Mount Hope Farm in Bristol, Rhode Island, where he was elected to the colonial assembly in 1761.
He expanded his abilities with the study of law, was admitted to the bar in 1767, and established a practice at Bristol.
When the British Navy bombarded Bristol on October 7, 1775, his home was among the buildings destroyed.
In 1790, she married James DeWolf of Bristol, who was a successful slave trader and belonged to a large and influential family that also went into banking and insurance.