De Los Santos wrote the original screenplay for Spun (Columbia Pictures/TriStar Pictures), a work inspired by his experience in the Eugene, Oregon drug subculture.

[8] De Los Santos wrote the screenplay adaptation for the upcoming motion-picture based on Iceberg Slim's novel, Mama Black Widow.

[9][10] De Los Santos along with Arizona writer, Stan Pirog, has co-written the screenplay for a film of the life of Plato entitled The Man of The Republic which is currently in development with producer Chris Hanley and his Muse Productions.

[14] In 2017 De Los Santos purchased the motion picture rights to the novel Wasting Talent from author Ryan Leone and adapted the story into a new script entitled Love in Vein.

[15] Writer Chris Campion, from Dazed & Confused Magazine, called De Los Santos, "...the most exciting American screenwriter of his generation...one minute he appears to be a deranged hustler trapped by mad ambition, and locked on a path determined by self-delusion.