Dufris began his audio career in London, where he appeared in several BBC Radio plays with Kathleen Turner, Sharon Gless, Stockard Channing, and Helena Bonham-Carter.

Moreover, he worked with director Dirk Maggs on his audio drama productions of Spider-Man (where he voiced the title role of Spider-Man/Peter Parker), Judge Dredd, Voyage and An American Werewolf in London.

Upon returning to the United States, Dufris founded Mind's Eye Productions and co-founded Rocky Coast Radio Theatre and The AudioComics Company, for which he has been producer, director, actor, and engineer.

He was a guest instructor and performer at the 2005–2007 Audio Theatre Workshops, appearing in the world premiere works The Best Place to Grow Pumpkins, Rewind, Extra-Ordinary, and Histories.

[4] Dufris was nominated twelve times as an audiobook finalist for the Audio Publishers Association's Audie Awards, winning in 2012 for Best Non-Fiction.