As a student pursuing his advanced level education at Mfantsipim School, his father arranged for him to spend his long vacations in Cotonou to improve his spoken French, and Benin subsequently became his first diplomatic station.
He served as supervisor of the Directorate for Policy Planning, Research and Monitoring for two years and in 2008 he was appointed Ghana's high commissioner to Zambia and also head of missions.
After the Fukushima nuclear accident in May 2011, the late John Evans Atta Mills appointed him Ghana's ambassador to Japan.
From 16 June 2011 to 31 December 2012, he was Ghana's ambassador to Japan with residence in Tokyo and was also accredited as high commissioner to Singapore.
Brandful signed the makeup contract of the real estate group Sakae Dori Maruzen Co. Ltd. in his private name, with his diplomatic identification.