William Henry Stone (November 7, 1828 – July 9, 1901) was a U.S. Representative from Missouri.

Born in Shawangunk, New York, Stone attended the common schools.

He became president of the St. Louis Hot Pressed Nut & Bolt Company upon its organization in 1867.

He served as member of the St. Louis Board of Water Commissioners from July 5, 1871, to November 15, 1873, when he resigned, having been elected to Congress.

He was not a candidate for renomination in 1876 to the Forty-fifth Congress, instead resuming business interests.