Holmes, heir to the Fleischmann's Yeast fortune, wanted to be an actor, so his father footed the bill for him to star in the early 1950s film Daughter of the Sun God.
In 1950, he acted in the musical Careless Rapture at the Dudley Hippodrome in Dudley, West Midlands, England, with Barry Sinclair, Mary Allen, Arthur Hosking, Muriel Barron, Joan Norman, and Charles Gillespie in the cast.
Louella Parsons wrote that Holmes would have the top role in the film Cocobolo, directed by Henry Herts and produced by Robert Peters.
Hedda Hopper wrote, "Bill Holmes, the yeast heir, is devoting his time to writing, acting, and Dorothy Malone.
[3] Mike Connolly reported that Holmes would marry Nancy Valentine in 1956, following Buchanan's Reno divorce.