William II Crispo (Guglielmo in Italian; 1390–1463) was the fifteenth Duke of the Archipelago, from 1453 to 1463.
He was the son of the tenth Duke Francesco I Crispo and wife Fiorenza I Sanudo, Lady of Milos.
He also signed a treaty with Sultan Mehmed II that recognized him as Duke and to live in peace and harmony with the Porte; he also received the right to fly the flag of St. Mark in his realm.
William Crispo married in 1461 or 1462 Nobil Donna Elisabetta da Pesaro, Patrizia Veneta, and their only child was:
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