William Joseph Burke (September 25, 1862 – November 7, 1925) was a British-born American politician and businessman.

In 1922, he ran for the United States Senate from Pennsylvania as a member of the Progressive Party and came in third place, receiving 8% of the vote.

In the early 1900s he became interested in the development of oil near Callery, Butler County.

He was involved with organized labor as a chairman of the Order of Railroad Conductors.

He was interred in the Roman Catholic Calvary Cemetery, Pittsburgh, Pennsylvania.