The William Penn Senior High School is a large, urban, public high school serving York, Pennsylvania in York County, Pennsylvania.

It is the sole high school operated by the School District of the City of York.

Among grades 9–12, 87.6% of pupils were eligible for a free lunch due to family poverty, as of 2014.

William Penn Senior High School students have access to a wide variety of clubs, activities and an extensive sports program.

The district provides: —according to PIAA directory, June 2015[4]