He is best known for his vocal performances, such as Reverend Putty on Moral Orel, Rigby on Regular Show and Otto Octavius / Doctor Octopus in the 2018 video game Spider-Man.

[1] He is known as the voice of Rigby on Regular Show, Reverend Putty and Mr. Littler on Moral Orel and Otto Octavius / Doctor Octopus in the video game Spider-Man.

Salyers also provided the voices of the Penguin in Batman: Return of the Caped Crusaders and Batman vs. Two-Face, Virman Vundabar in Justice League Action, Truman Marsh in Avengers Assemble, Hoffman in Back 4 Blood, and Bruce Banner in Marvel's Midnight Suns.

He has also had live-action roles in the film Bedazzled and the television series Judging Amy.

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