The new school was officially opened by the First Minister of Scotland, Jack McConnell, on Monday 11 December 2006.

Following an inspection in 2009, Williamwood became the first school in Scotland to be awarded a maximum of five "excellent" ratings by Her Majesty's Inspectorate of Education.

The former playing fields were redeveloped into the Eastwood Health Centre, alongside the old Isobel Mair School building.

[5] In April 2015, the S6 year group from the school went viral on the internet after filming a video of themselves and various staff members miming to the song Uptown Funk by Bruno Mars and Mark Ronson.

The video was made to be shown at their end of year graduation but amassed over one hundred thousand views after being posted online.

Soon after the appointment, the school implemented a controversial new rule that toilets were to be locked during class time to prevent truancy.

Critics argue that the move undermines female representation, while supporters believe it is a step towards gender equality.

The school's decision has sparked a broader debate on gender roles in educational leadership.