Her research focused primarily on eels, minnows, pike, and char by observing fish in the wild.
[1] Frost worked with Professor James Johnstone researching euphausids at Liverpool University, where she also earned her Master of Science in zoology in 1926.
Starting in 1938, Frost worked as an assistant inspector studying trout in the River Liffey for the Fisheries Branch in Dublin.
[2] In 1945, the quality of her published work encouraged Liverpool University to grant Frost her Doctor of Science.
Frost was also a member of the Council of Salmon and Trout Association, which facilitated her travel to central Africa where she studied eels.