It runs through the suburbs of Fort Rouge, River Heights, Tuxedo, and Charleswood.

It is the eastern extension of Provincial Road 241, which runs westward to the communities of Headingley and Lido Plage.

Within the city boundaries it connects the residential and light industrial areas west-southwest of downtown with the Pembina Highway and downtown.

[2][3] Route 105 begins at the Pembina Highway and runs westward as Grant Avenue through Fort Rouge, River Heights, and Tuxedo, then passes through the Assiniboine Forest while multiplexed with Route 96.

It then becomes Roblin Boulevard, passing through central and west Charleswood before meeting the city limits at the Perimeter Highway.