The highway begins at its intersection with WIS 13 and 153rd Road north of Stratford and continues eastward from it.

It passes by WIS 97 (North Weber Avenue) in Stratford and various small communities before it enters Moisinee.

It later runs north towards Mission Lake Road and continues east along its alignment, intersecting WIS 49 before ending at US 45 in the town of Wittenberg.

The section west of WIS 97 was signed as CTH-M.[3] In 1927, the same year WIS 10 was redesignated as US 51, a section east of US 51 was signed as CTH-K.[4] In 1939, a bill proposing an extension of the highway was heard in the Wisconsin Legislature, though this was indefinitely postponed.

[6][7] A third extension was built in 1961 or 1962, extending the highway 6 miles (10 km) further east from Elderon along CTH-K to its present eastern terminus at US 45 near Whitcomb.