[2] For its entire length, the WIS 180 roughly follows the western bank of the Menominee River as a two-lane road.

After promptly crossing a bridge over the Wright Slough of the Menominee River, WIS 180 continues its northeasterly course for about 6.5 miles (10.5 km) before reaching the eastern end of CTH-G in the unincorporated community of Rubys Corner.

About 3.9 miles (6.3 km) farther along its route, WIS 180 connects with the eastern end of CTH-X on the southeast corner of Menominee River County Park.

WIS 180 then connects with the southern end of CTH-RR, almost immediately after its junction with CTH-JJ.

From McAllister, WIS 180 heads westerly for about 12.3 miles (19.8 km) until it reaches its northern terminus at US 141 on the southern border of the village of Wausaukee.