WIS 105 serves as an east–west arterial route between the city of Superior, the village of Oliver, and the Gary-New Duluth neighborhood of Duluth that passes through the Town of Superior.

The western terminus of WIS 105 is at the state line with Minnesota at the Oliver Bridge.

After crossing the river, WIS 105 becomes Minnesota State Highway 39 (MN 39, East McCuen Street).

[1] From its western terminus, WIS 105 runs east-west through Oliver, intersecting with County Trunk Highway W (CTH-W) in western Oliver.

It then runs east-west through southern Superior before ending at an intersection with WIS 135.