Wiscoy Creek is a stream, approximately 15 miles (24 km) long,[3] in western New York in the United States.

[1] In the hamlet of Bliss the creek is joined by its North Branch, which flows south from its source in the Town of Wethersfield.

[3] Nursed by cold springs, the water temperature in this stream rarely exceeds 70 °F (21 °C), enabling the Wiscoy to provide good trout fishing all season long.

The stream is managed almost exclusively as a wild trout fishery; the only stretch that is stocked is a one-mile (1.6 km) section in Allegany County.

A 2006 New York State Department of Environmental Conservation survey estimated 1,600 adult wild brown trout per stream mile in the Wyoming County section of Wiscoy Creek.