The song reached The Billboard 100, as well as the Adult Contemporary and Christian music charts in the United States.

"Wise Up" is an uptempo, inspirational song with a rock sound, featuring heavy percussion and guitars.

During the 1988-89 Lead Me On Tour, Grant performed an updated rendition of "Wise Up" as a regular part of her set list.

The song was also given a "Big Beats" dance remix, which featured, among other things, additional sound effects and Grant repeating the phrase "Pack 'em up, move 'em out".

2 spot on the Christian music charts in the U.S. On mainstream radio, "Wise Up" didn't rise as high as "Find a Way", but performed slightly better than the previous single, "Everywhere I Go".