Yancy Butler starred as Sara Pezzini, Anthony Cistaro as Kenneth Irons, David Chokachi as Jake McCartey, Eric Etebari as Ian Nottingham, Will Yun Lee as Danny Woo, Conrad Dunn as Tommy Gallo, Kenneth Welsh as Joe Siri, and John Hensley as Gabriel Bowman, among others.

In spite of its cancellation, Witchblade was ranked seventh in the Top 10 Basic Cable Dramas for 2002 (Multichannel News, February 2003).

Acts like Stabbing Westward, Pump, Michael Kisur, and Suicidal Tendencies were featured in the show soundtrack.

On May 29, 2007, the soundtrack for the series' score was released by composer Joel Goldsmith on his independent record label, FreeClyde.

Johnson calls it "a nice action series to enjoy in the summer, full of atmospheric characters and situations".