When the growing collection grew too large for the high school where it was housed, Schulz and her supporters appealed to the city council for funds to build a new museum.

[10] The two log cabins on the property were constructed by participants in President Roosevelt's National Youth Administration program and are frequently used to teach students about pioneer life.

1940s: Two historic San Antonio houses were moved from their original locations to the Witte Museum campus; the limestone home of banker John Twohig, an Irish born pioneer San Antonio merchant, and the plastered stone home of José Francisco Ruiz, who was the city's first schoolmaster and one of two native Texans to sign the Texas Declaration of Independence.

[17] The oldest and one of the largest public circus collections, it includes artifacts, programs, prints and photographs, as well as sheet music, videotapes, professional journals and published manuscripts.

The collections are links to the area's heritage and include saddles, spurs, basketry, branding irons, historical clothing, land grants, art and firearms.

[26] The ribbon cutting and grand opening took place on March 4, 2017, and was attended by Witte President and CEO Marise McDermott, Texas First Lady Cecilia Abbott, US Congressman Lamar Smith, Bexar County Judge Nelson Wolff, Mayor Ivy Taylor and Councilman Alan Warrick, among others.