It passes the Wolf River Game Management Area.

Wolf River discharges at the Bay of St. Louis which is known as Dimitry Point and the region is known as Alexander Dimitry Claim.

Red wolves no longer inhabit the river region but other wildlife such as foxes, coyotes, turkeys, and songbirds can be found in the area.

During the 1800s, the river was used to transport lumber, brick, charcoal, and cordwood.

[3] Wolf River is a popular destination for canoers and kayakers.