The Wolfe Music Building was built at a time when Euclid Avenue was transitioning from the residential Millionaire's Row to a street that was quickly becoming an up-and-coming showcase for arts, culture, and commerce.

The building was designed by Walker and Weeks, arguably one of the most important architecture firms in Cleveland's history, and contracted to the Crowell and Little Construction Company.

The structure was designed with the music store in mind, with adequate retail, showroom, and rehearsal space.

[10] In the fall of 2012, however, the building was approved for demolition to make way for CSU's $45 million Center for Innovation in Health Professions.

[11] The building was demolished shortly thereafter; the CSU Center for Innovation in Medical Professions opened in September 2015.